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Орексинергическая система мозга и патогенетические основы нарушений цикла «сон – бодрствование» при нарколепсии

https://doi.org/10.20538/1682-0363-2017-4-7-15

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Аннотация

Сон является одной из важнейших витальных функций, и изучение основных механизмов, в результате которых нарушается регуляция цикла «сон – бодрствование», выступает одной из приоритетных задач современной медицинской науки. Известно, что система орексин-содержащих нейронов гипоталамуса, сигналы от которых поступают во все центры бодрствования, играет ведущую роль в инициации и поддержании этого состояния. Недостаточность функции орексинергической системы гипоталамуса приводит к нарушениям цикла «сон – бодрствование» и развитию тяжелых заболеваний – нарколепсии и катаплексии. Представленный обзор посвящен рассмотрению возможных механизмов развития патологических изменений функций орексин-содержащих нейронов гипоталамуса и заболеваний, обусловленных ими. 

Об авторах

Ю. В. Гаврилов
Институт экспериментальной медицины (ИЭМ)
Россия

канд. мед. наук, ст. науч. сотрудник

отдел общей патологии и патологической физиологии

197376, г. Санкт-Петербург, ул. Академика Павлова, 12 



К. З. Деревцова
Институт экспериментальной медицины (ИЭМ)
Россия

канд. биол. наук, ст. науч. сотрудник

отдел общей патологии и патологической физиологии

197376, г. Санкт-Петербург, ул. Академика Павлова, 12 



Е. А. Корнева
Институт экспериментальной медицины (ИЭМ); Санкт-Петербургский государственный университет
Россия

академик РАН, д-р мед. наук, гл. науч. сотрудник

отдел общей патологии и патологической физиологии

197376, г. Санкт-Петербург, ул. Академика Павлова, 12 

профессор

кафедра патофизиологии

199034, г. Санкт-Петербург, Университетская наб., 7–9 



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Для цитирования:


Гаврилов Ю.В., Деревцова К.З., Корнева Е.А. Орексинергическая система мозга и патогенетические основы нарушений цикла «сон – бодрствование» при нарколепсии. Бюллетень сибирской медицины. 2017;16(4):7-15. https://doi.org/10.20538/1682-0363-2017-4-7-15

For citation:


Gavrilov Yu.V., Derevtsova K.Z., Korneva H.A. Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy. Bulletin of Siberian Medicine. 2017;16(4):7-15. (In Russ.) https://doi.org/10.20538/1682-0363-2017-4-7-15

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ISSN 1682-0363 (Print)
ISSN 1819-3684 (Online)