Бюллетень сибирской медицины

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Роль лизосомальных цистеиновых протеиназ в опухолевой прогрессии

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Рассматриваeтся роль лизосомальных цистеиновых протеаз в опухолевой прогрессии. Подробно aнализируется значимость катепсинов в процессах клеточной пролиферации, апоптоза, ангиогенеза, инвазии и метастазирования раковых клеток. Особое внимание уделено обсуждению молекулярных механизмов участия катепсинов в отдельных этапах раковой прогрессии, включающих протеолитическую деградацию компонентов внеклеточного матрикса, активацию предшественников сериновых протеаз и плазминогена. Более того, катепсины стромальных клеток также принимают участие в процессах раковой прогрессии и формирования метастаз и могут являться потенциальными мишенями для противораковой терапии.

Об авторах

М. С. Коровин
Сибирский государственный медицинский университет

Коровин Матвей Сергеевич, аспирант кафедры патофизиологии 


В. В. Новицкий
Сибирский государственный медицинский университет
д р мед наук профессор академик РАМН зав кафедрой патофизиологии

О. С. Васильева
Институт имени И. Стефана
канд мед наук

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Для цитирования:

Коровин М.С., Новицкий В.В., Васильева О.С. Роль лизосомальных цистеиновых протеиназ в опухолевой прогрессии. Бюллетень сибирской медицины. 2009;8(2):85-90.

For citation:

Korovin M.S., Novitsky V.V., Vasiliyeva O.S. The role of lysosomal cysteine proteases in tumor progression. Bulletin of Siberian Medicine. 2009;8(2):85-90. (In Russ.)

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