Preview

Бюллетень сибирской медицины

Расширенный поиск

Образование и биологическая роль NO при аллергическом воспалении

https://doi.org/10.20538/1682-0363-2009-3-95-104

Полный текст:

Аннотация

Рассмотрены пути и механизмы образования оксида азота. Проанализированы эффекты метаболитов оксида азота в регуляции аллергического воспаления. Представлены современные данные участия оксида азота в формировании окислительного и нитрозилирующего стрессов, в регуляции основных внутриклеточных сигнальных путей, в реализации про- и антиапоптотических эффектов.

Об авторах

О. В. Козина
Центр по профилактике и борьбе со СПИД и ИЗ
Россия

Козина Ольга Владимировна, канд мед наук врач

8 (415-2) 42-17-22, 8-962-280-6562



Л. М. Огородова
Сибирский государственный медицинский университет
Россия
заслуженный деятель науки РФ д р мед наук профессор член корреспондент РАМН зав кафедрой факультетской педиатрии с курсом детских болезней лечебного факультета


Список литературы

1. Андреева Н.А., Шуматова Т.А., Мотавкин П.А. Нитрооксидергические нейроны органов дыхания//Бюл. эксперим. биологии и медицины. 2000. Т. 129. № 2. С. 222-224.

2. Ли Д.Д., Ян Р.В., Луо Х., Зу Г. Реакции пероксинитрита и нитрита с органическими молекулами и гемоглобином//Биохимия. 2005. Т. 70, № 10. С. 1423-1431.

3. Осипов А.Н., Борисенко Г.Г., Владимиров Ю.А. Биологическая роль нитрозильных комплексов гемопротеинов//Успехи биол. химии. 2007. № 7. С. 59-292.

4. Adler K.B., Li Y. Airway epithelium and mucus: intracellular signaling pathways for gene expression and secretion//Am. J. Respir. Cell Mol. Biol. 2001. V. 5. P. 397-400.

5. Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases: structure, function and inhibition//Biochem. J. 2001. V. 357. P. 593-615.

6. Baker P.R., Lin Y., Schopfer F.J. Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands//J. Biol. Chem. 2005. V. 280. P. 42464-42475.

7. Ballou D.P., Zhao Y., Brandish P.E., Marletta M.A. Revisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: the simple NO-binding model is incorrect.//Proc. Natl. Acad. Sci. USA. 2002. V. 99. P. 12097-12101.

8. Bellamy T.C., Griffiths V., Garthwaite J. Differential sensitivity of guanylyl cyclase and mitochondrial respiration to nitric oxide measured using clamped concentrations//J. Biol. Chem. 2002. V. 277. P. 31801-31807.

9. Birnboim H.C., Lemay A.M., Lam D.K. Cutting edge: MHC class II-restricted peptides containing the inflammation-associated marker 3-nitrotyrosine evade central tolerance and elicit a robust cell-mediated immune response//J. Immunol. 2003. V. 171. P. 528-532.

10. Bogdan C. Nitric oxide and the immune response//Nat. Immunol. 2001. V. 2. P. 907-916.

11. Bogdan C. Nitric oxide and the regulation of gene expression//Trends Cell Biol. 2001. V. 11. P. 66-75.

12. Bove P., van der Vliet A. Nitric oxide and reactive nitrogen species in airway epithelial signaling and inflammation//Free Radic. Biol. Med. 2006. V. 41, № 4. P. 515-527.

13. Broide D.H., Lawrence T., Doherty T. et al. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium//Proc. Natl. Acad. Sci. USA. 2005. V. 102. P. 17723-17728.

14. Brune B. Nitric oxide: NO apoptosis or turning it ON?//Cell. Death. Differ. 2003. V. 10. P.864-869.

15. Celio S., Troxler H., Durka S. et al. Free 3-nitrotyrosine in exhaled breath condensates of children fails as a marker for oxidative stress in stable cystic fibrosis and asthma//Nitric Oxide <http://www.sciencedirect.com/science/journal/10898603>. 2006. V. 15, № 3. P. 226-232.

16. Connelly L., Jacobs A.T., Palacios-Callender M. et al. Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression//J. Biol. Chem. 2003. V. 278. P. 26480-26487.

17. Cooper C.E. Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?//Trends Biochem. Sci. 2002. V. 27. P. 33-39.

18. Darling K.E., Evans T.J. Effects of nitric oxide on Pseudomonas aeruginosa infection of epithelial cells from a human respiratory cell line derived from a patient with cystic fibrosis//Infect. Immun. 2003. V. 71. P. 2341-2349.

19. De Sanctis G.T., MacLean J.A., Hamada K. et al. Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma//J. Exp. Med. 1999. V. 189. P. 1621-1630.

20. Delhase M., Hayakawa M., Chen Y., Karin M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation//Science 1999. V. 284. P. 309-313.

21. Diamond G., Legarda D., Ryan L.K. The innate immune response of the respiratory epithelium//Immunol. Rev. 2000. V. 173. P. 27-38.

22. Dinakar C. Exhaled nitric oxide in the clinical management of asthma//Curr. Allergy Asthma Rep. 2004. V. 4. P. 454-459.

23. Dweik R., Comhair S., Gaston B. et al. NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response//PNAS. 2001. V. 98, № 5. P. 2622-2627.

24. Dweik R.A., Comhair S.A., Gaston B. NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response.//Proc. Natl. Acad. Sci. USA. 2001. V. 98. P. 2622-2627.

25. Eriksson U., Egermann U., Bihl M.P. et al. Human bronchial epithelium controls Th2 responses by Th1-induced, nitric oxide-mediated STAT5 dephosphorylation: implications for the pathogenesis of asthma//J. Immunol. 2005. V. 175. P. 2715-2720.

26. Erwin P.A., Mitchell D.A., Sartoretto J. et al. Subcellular targeting and differential S-nitrosylation of endothelial nitric-oxide synthase//J. Biol. Chem. 2006. V. 281. P. 151-157.

27. Fang K., Johns R., Macdonald T. et al. S-nitrosoglutathione breakdown prevents airway smooth muscle relaxation in the guinea pig//Am. J. Physiol. Lung Cell. Mol. Physiol. 2000. V. 279. P. 716-721.

28. Friebe A., Koesling D. Regulation of nitric oxide-sensitive guanylyl cyclase//Circ. Res. 2003. V. 93. P. 96-105.

29. Gaston B., Reilly J., Drazen J.M. et al. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways//Proc. Natl. Acad. Sci. USA. 1993. V. 90. P. 10957-10961.

30. Gaston B., Sears S., Woods J. et al. Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure//Lancet. 1998. V. 351. P. 1317-1319.

31. Gaston B.M., Carver J., Doctor A., Palmer L.A. S-Nitrosylation signaling in cell biology//Mol. Interv. 2003. V. 3. P. 253-263.

32. Giustarini D., Milzani A., Colombo R. et al. Nitric oxide and S-nitrosothiols in human blood//Clinica Chimica Acta. 2003. V. 330. № 1-2. P. 85-98.

33. Gookin J.L., Rhoads J.M., Argenzio R.A. Inducible nitric oxide synthase mediates early epithelial repair of porcine ileum//Am. J. Physiol. Gastrointest. Liver Physiol. 2002. V. 283. P. 157-168.

34. Grasemann H., Gaston B., Fang K. et al. Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function//J. Pediatr. 1999. V. 135. P. 770-772.

35. Gu Z., Kaul M., Yan B. et al. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death//Science. 2002. V. 297. P. 1186-1190.

36. Guo F.H., Comhair S.A., Zheng S. et al. Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis//J. Immunol. 2000. V. 164. P. 5970-5980.

37. Hamad A.M., Clayton A., Islam B., Knox A.J. Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function//Am. J. Physiol. Lung Cell. Mol. Physiol. 2003. V. 285. P. 973-983.

38. Han X., Fink M.P., Uchiyama T. et al. Increased iNOS activity is essential for pulmonary epithelial tight junction dysfunction in endotoxemic mice//Am. J. Physiol. Lung Cell. Mol. Physiol. 2004. V. 286. P. 259-267.

39. Hara M.R., Agrawal N., Kim S.F. et al. S-Nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding//Nat. Cell Biol. 2005. V. 7. P. 665-674.

40. Hardiman K.M., McNicholas-Bevensee C.M., Fortenberry J. et al. Regulation of amiloride-sensitive Na+ transport by basal nitric oxide//Am. J. Respir. Cell Mol. Biol. 2004. V. 30. P. 720-728.

41. He B., Weber G.F. Phosphorylation of NF-kappaB proteins by cyclic GMP-dependent kinase. A noncanonical pathway to NF-kappaB activation//Eur. J. Biochem. 2003. V. 270. P. 2174-2185.

42. Helms M.N., Yu L., Malik B. Role of SGK1 in nitric oxide inhibition of ENaC in Na+-transporting epithelia//Am. J. Physiol. Cell Physiol. 2005. V. 289. P. 717-726.

43. Hemish J., Nakaya N., Mittal V., Enikolopov G. Nitric oxide activates diverse signaling pathways to regulate gene expression//J. Biol. Chem. 2003. V. 278. P. 42321-42329.

44. Hess D.T., Matsumoto A., Kim S.O. et al. Protein S-nitrosylation: purview and parameters//Nat. Rev., Mol. Cell Biol. 2005. V. 6. P. 150-166.

45. Hjoberg J., Shore S., Kobzik L. et al. Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness//J. Appl. Physiol. 2004. V. 97. P. 249-259.

46. Hogg N. The biochemistry and physiology of S-nitrosothiols//Annu. Rev. Pharmacol. Toxicol. 2002. V. 42. P. 585-600.

47. Ichikawa T., Sugiura H., Koarai A. et al. Peroxynitrite augments fibroblast mediated tissue remodeling via myofibroblast differentiation//Am. J. Physiol. Lung. Cell. Mol. Physiol. 2008. V. 295. № 5. P. 800-808.

48. Ischiropoulos H. Biological selectivity and functional aspects of protein tyrosine nitration//Biochem. Biophys. Res. Commun. 2003. V. 305. P. 776-783.

49. Ischiropoulos H., Zhu L., Beckman J. Peroxynitrite formation from macrophage derived nitric oxide//Arch. Biochem. Biophys. 1992. V. 298. P. 446-451.

50. Jain B., Rubinstein I., Robbins R.A. et al. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide//Biochem. Biophys. Res. Commun. 1993. V. 191. P. 83-88.

51. Janssen-Heininger Y.M., Poynter M.E., Baeuerle P.A. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB//Free Radic. Biol. Med. 2000. V. 28. P. 1317-1327.

52. Kalra D., Baumgarten G., Dibbs Z. et al. Nitric oxide provokes tumor necrosis factor-alpha expression in adult feline myocardium through a cGMP-dependent pathway//Circulation. 2000. V. 102. P. 1302-1307.

53. Kilani M.M., Mohammed K.A., Nasreen N. RSV causes HIF-1 alpha stabilization via NO release in primary bronchial epithelial cells//Inflammation. 2004. V. 28. P. 245-251.

54. Kim S.F., Huri D.A., Snyder S.H. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2//Science. 2005. V. 310. P. 1966-1970.

55. Knight D.A., Holgate S.T. The airway epithelium: structural and functional properties in health and disease//Respirology. 2003. V. 8. P. 432-446.

56. Kuwano K. Epithelial Cell Apoptosis and Lung Remodeling//Cell. Mol. Immunol. 2007. V. 4. № 6. P. 419-429.

57. Li C.Q., Wogan G.N. Nitric oxide as a modulator of apoptosis//Cancer Lett. 2005. V. 226. P. 1-15.

58. Li D., Shirakami G., Zhan X., Johns R.A. Regulation of ciliary beat frequency by the nitric oxide-cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells//Am. J. Respir. Cell Mol. Biol. 2000. V. 23. P. 175-181.

59. Liu L., Hausladen A., Zeng M. et al. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans//Nature. 2001. V. 410. P. 490-494.

60. Maarsingh H., Bossenga B.E., Bos I.S. et al. L-Arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction//Eur. Respir. J. 2009. in press.

61. MacPherson J.C., Comhair S.A., Erzurum S.C. et al. Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species//J. Immunol. 2001. V. 166. P. 5763-5772.

62. Marshall H.E., Stamler J.S. Nitrosative stress-induced apoptosis through inhibition of NF-kappa b//J. Biol. Chem. 2002. V. 277. P. 34223-34228.

63. Matata B.M., Galinanes M. Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-kappa B DNA binding activity//J. Biol. Chem. 2002. V. 277. P. 2330-2335.

64. Mitchell D.A., Marletta M.A. Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine//Nat. Chem. Biol. 2005. V. 1. P. 154-158.

65. Moncada S., Erusalimsky J.D. Does nitric oxide modulate mitochondrial energy generation and apoptosis?//Nat. Rev. Mol. Cell. Biol. 2002. V. 3. P. 214-220.

66. Okamoto T., Akuta T., Tamura F. et al. Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation//Biol. Chem. 2004. V. 385. P. 997-1006.

67. Okamoto T., Gohil K., Finkelstein E.I. et al. Multiple contributing roles for NOS2 in LPS-induced acute airway inflammation in mice//Am. J. Physiol. Lung Cell. Mol. Physiol. 2004. V. 286. P. 198-209.

68. Okamoto T., Valacchi G., Gohil K. et al. S-Nitrosothiols inhibit cytokine-mediated induction of matrix metalloproteinase-9 in airway epithelial cells//Am. J. Respir. Cell. Mol. Biol. 2002. V. 27. P. 463-473.

69. Park S.W., Huq M.D., Hu X., Wei L.N. Tyrosine nitration on p65: a novel mechanism to rapidly inactivate nuclear factor-kappaB//Mol. Cell. Proteomics 2005. V. 4. P. 300-309.

70. Park S.W., Sung M.W., Heo D.S. Nitric oxide upregulates the cyclooxygenase-2 expression through the cAMP-response element in its promoter in several cancer cell lines//Oncogene. 2005. V. 24. P. 6689-6698.

71. Parks W.C., Wilson C.L., Lopez-Boado Y.S. Matrix metalloproteinases as modulators of inflammation and innate immunity//Nat. Rev. Immunol. 2004. V. 4. P. 617-629.

72. Pilz R.B., Casteel D.E. Regulation of gene expression by cyclic GMP//Circ. Res. 2003. V. 93. P. 1034-1046.

73. Poynter M.E., Cloots R., van Woerkom T. et al. NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness//J. Immunol. 2004. V. 273. P. 7003-7009.

74. Que L.G., Liu L., Yan Y. et al. Protection from experimental asthma by an endogenous bronchodilator//Science. 2005. V. 308. P. 1618-1621.

75. Que L.G., Yang Z., Stamler J.S. S-Nitrosoglutathione Reductase -an important regulator in human asthma//Am. J. Respir. Crit. Care. Med. 2009 (in press).

76. Radi R. Nitric oxide, oxidants, and protein tyrosine nitration//Proc. Natl. Acad. Sci. USA. 2004. V. 101. P. 4003-4008.

77. Razavi H.M., Wang le F., Weicker S. et al. Pulmonary neutrophil infiltration in murine sepsis: role of inducible nitric oxide synthase//Am. J. Respir. Crit. Care Med. 2004. V. 170. P. 227-233.

78. Reynaert N.L., Ckless K., Korn S.H. et al. Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation//Proc. Natl. Acad. Sci. USA. 2004. V. 101. P. 8945-8950.

79. Reynaert N.L., Ckless K., Wouters E.F. Nitric oxide and redox signaling in allergic airway inflammation//Antioxid. Redox. Signal. 2005. V. 7. P. 129-143.

80. Richardson G., Benjamin N. Potential therapeutic uses for S-nitrosothiols//Clin. Sci. Lond. 2002. V. 102. P. 99-105.

81. Rose F., Guthmann B., Tenenbaum T. et al. Apical, but not basolateral, endotoxin preincubation protects alveolar epithelial cells against hydrogen peroxide-induced loss of barrier function: the role of nitric oxide synthesis//J. Immunol. 2002. V. 169. P. 1474-1481.

82. Sadikot R.T., Zeng H., Joo M. Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa//J. Immunol. 2006. V. 176. P. 4923-4930.

83. Saleh D., Ernst P., Lim S. et al. Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid//FASEB J. 1998. V. 12. P. 929-937.

84. Sellak H., Yang X., Cao X. Sp1 transcription factor as a molecular target for nitric oxide and cyclic nucleotide Mediated suppression of cGMP-dependent protein kinase-Ialpha expression in vascular smooth muscle cells//Circ. Res. 2002. V. 90. P. 405-412.

85. Silkoff P.E., McClean P., Caramori M. et al. A significant proportion of exhaled nitric oxide arises in large airways in normal subjects//Respir. Physiol. 1998. V. 113, № 1. P. 33-38.

86. Snyder A., McPherson M., Hunt J. et al. Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis//Am. J. Respir. Crit. Care Med. 2002. V. 165. P. 22-926.

87. Sparkman L., Boggaram V. Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells//Am. J. Physiol. Lung Cell. Mol. Physiol. 2004. V. 287. P. 764-773.

88. Speyer C.L., Neff T.A., Warner R.L. et al. Regulatory effects of iNOS on acute lung inflammatory responses in mice//Am. J. Pathol. 2003. V. 163. P. 2319-2328.

89. Spiecker M., Peng H.B., Liao J.K. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaB alpha//J. Biol. Chem. 1997. V. 272. P. 30969-30974.

90. Trujillo M., Alvarez M.N., Peluffo G. et al. Xanthine oxidase-mediated decomposition of S-nitrosothiols//J. Biol. Chem. 1998. V. 273. P. 7828-7834.

91. van der Vliet A., Eiserich J.P., Shigenaga M.K., Cross C.E. Reactive nitrogen species and tyrosine nitration in the respiratory tract: epiphenomena or a pathobiologic mechanism of disease?//Am. J. Respir. Crit. Care. Med. 1999. V. 160. P. 1-9.

92. van der Vliet A., Hoen P.A., Wong P.S. et al. Formation of S-nitrosothiols via direct nucleophilic nitrosation of thiols by peroxynitrite with elimination of hydrogen peroxide//J. Biol. Chem. 1998. V. 273. P. 30255-30262.

93. Van Der Vliet A., Nguyen M.N., Shigenaga M.K. et al. Myeloperoxidase and protein oxidation in cystic fibrosis//Am. J. Physiol. Lung Cell. Mol. Physiol. 2000. V. 279. P. 537-546.

94. Watkins D.N., Garlepp M.J., Thompson P.J. Regulation of the inducible cyclo-oxygenase pathway in human cultured airway epithelial (A549) cells by nitric oxide//Br. J. Pharmacol. 1997. V. 121. P. 1482-1488.

95. Xu W., Zheng S., Dweik R.A., Erzurum S.C. The role of epithelial NO in airway viral infection//Free Radic. Biol. Med. 2006. V. 41. № 1. P. 19-28.

96. Yamasaki K., Edington H.D., McClosky C. et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer//J. Clin. Invest. 1998. V. 101. P. 967-971.

97. Zandi E. Karin M. Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex//Mol. Cell. Biol. 1999. V. 19. P. 4547-4551.

98. Zeidler M.R., Kleerup E.C., Tashkin D.P. Exhaled nitric oxide in the assessment of asthma//Curr. Opin. Pulm. Med. 2004. V. 10. P. 31-36.

99. Zhang X., Moilanen E., Lahti A. et al. Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer andactivator of transcription 5//J. Allergy. Clin. Immunol. 2003. V. 112. P. 93-101.

100. Zhang Y., Hogg N. S-Nitrosothiols: cellular formation and transport//Free Radic. Biol. Med. 2005. V. 38. P. 831-838.

101. Zheng S., De B.P., Choudhary S. Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis//Immunity. 2003. V. 18. P. 619-630.


Для цитирования:


Козина О.В., Огородова Л.М. Образование и биологическая роль NO при аллергическом воспалении. Бюллетень сибирской медицины. 2009;8(3):95-104. https://doi.org/10.20538/1682-0363-2009-3-95-104

For citation:


Kozina O.V., Ogorodova L.M. Formation and biological role NO at an allergic inflammation. Bulletin of Siberian Medicine. 2009;8(3):95-104. (In Russ.) https://doi.org/10.20538/1682-0363-2009-3-95-104

Просмотров: 140


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1682-0363 (Print)
ISSN 1819-3684 (Online)